This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: All relevant data are within the paper and its Supporting Information files.įunding: This work was supported by the National Institute of Health R01 CA193380 ( ) to CTL and National Institute of Health R01 CA195500 ( ) to NR. Received: DecemAccepted: JanuPublished: February 9, 2018Ĭopyright: © 2018 Lam et al. Anderson, The Francis Crick Institute, UNITED KINGDOM (2018) An integrated strategy for improving contrast, durability, and portability of a Pocket Colposcope for cervical cancer screening and diagnosis. The primary outcome measures were the level of agreement (%) and κ ( kappa) statistic between the standard-of-care colposcope and each Pocket Colposcope (Generation 3 and Generation 4).Ĭitation: Lam CT, Mueller J, Asma B, Asiedu M, Krieger MS, Chitalia R, et al. Corresponding pathology was obtained for all image pairs. The paired images were blinded by device, randomized, and sent to an expert physician who provided a diagnosis for each image.
Specifically, paired images of cervices were collected from the standard-of-care colposcope and either the Generation 3 (n = 24 patients) or the Generation 4 (n = 32 patients) Pocket Colposcopes. A pilot clinical study was conducted to compare the Generation 3 and 4 Pocket Colposcopes to a standard-of-care colposcope (Leisegang Optik 2). Both systems were characterized with a series of bench tests to assess specular reflection, beam pattern uniformity, and image contrast. The reflector design (including the angle and height of the reflector sidewalls) was optimized through ray-tracing simulations.
Cross-polarization (Generation 3 Pocket Colposcope) and a new reflector design (Generation 4 Pocket Colposcope) were used to reduce glare and improve contrast.
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